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Sandoval and Klaus Weber reported in 1978 that large microtubule-associated proteins MAP1 and MAP2 (that are crucial for tubulin assembly) are rapidly degraded in crude brain extracts by a calcium-dependent protease, which does not affect tubulin, and this event results in the permanent loss of tubulin polymerization (Sandoval and Weber, 1978)

FDA approves olezarsen to reduce acute pancreatitis risk in severe hypertriglyceridemia by Bob Alaburda Tryngolza becomes the first therapy shown to lower the rate of acute pancreatitis in adults with triglycerides of at least 500 mg/dL, broadening an indication first granted for familial chylomicronemia syndrome in 2024

Most patients regain 13 pounds during that week due to increased hunger and water retention, but returning to your regular schedule resumes weight loss after 23 doses

Diarrhea occurs in approximately 30% of patients taking semaglutide 2.4 mg (Wegovy) and 19-23% of patients taking tirzepatide (Zepbound) according to FDA prescribing information